- Without FSL (FMRIB Software Library): Steep learning curve for beginners without prior neuroimaging experience
- Without FSL (FMRIB Software Library): Primarily designed for Linux and macOS; Windows support is limited and requires workarounds
- Without FSL (FMRIB Software Library): User interface is less modern compared to some commercial neuroimaging software
- Without FSL (FMRIB Software Library): Limited direct integration with cloud platforms out of the box